NR (Nicotinamide Riboside)
A form of vitamin B3 and a precursor to NAD+. Like NMN, it is used to raise NAD+ levels to support energy metabolism and healthy aging, with a well-studied oral safety profile.
How it works
Converted to NMN and then NAD+ via the salvage pathway (NRK enzymes). Higher NAD+ supports sirtuins, DNA repair, and mitochondrial energy production.
Key facts
- Molecular weight: 255.25 Da
- Half-life: Short; rapidly converted to NAD+
- Bioavailability: Oral absorption well documented
- Storage: Keep cool, dry, and sealed; refrigeration extends shelf life.
Dosing overview
- Typical dose: 250-1000 mg per day
- Frequency: Once daily
- Duration: Ongoing
- Route: Oral
Protocol notes
- Common range is ~250-1000 mg once daily, often in the morning.
- Frequently combined with other NAD+ support or longevity supplements.
- Taken with or without food.
Reported benefits
- Raises NAD+ levels
- Supports mitochondrial energy
- Well-studied oral safety
- Studied for metabolic and cardiovascular health
Possible side effects
- Generally well tolerated
- Mild nausea or flushing (uncommon)
- GI upset at high doses
Research
- Nicotinamide riboside raises NAD+ in humans (2018): Oral NR dose-dependently increased blood NAD+ and was well tolerated in healthy adults.
Compare NR
Community discussions about NR
- NR gave me weird GI stuff at 1,000 mg, anyone else see that? - 4 comments
- New NR Study Shows Modest NAD+ Boost – Worth the Hype or Just a Trend? - 4 comments
- NR made my stomach weird, anyone else see that? - 7 comments
- RNZ asking what we actually know about peptides - 4 comments
- Question about Apigenin and sleepiness next day - 6 comments
- Ask the community about NR
Research and educational reference only. Not medical advice.