NR made my stomach weird, anyone else see that?

Posted by amber464 in Safety & Side Effects - 16 points, 7 comments.

I’ve been messing with NR on and off, usually 500 mg in the morning, and for me the main thing I noticed wasn’t some magic energy boost. It was GI weirdness. If I take it on an empty stomach, I sometimes get this mild nausea and a tight, off feeling in my gut for a couple hours. Could just be me, but it’s been repeatable enough that I quit pretending it was random.

What’s interesting is it seems way better with food, especially after eggs or yogurt. No dramatic flushing for me, just that stomach annoyance if I’m sloppy with timing. I track resting HR, sleep, and general mood, and honestly the numbers didn’t move much. Maybe a tiny bump in morning alertness, but that could easily be placebo and better sleep the night before.

I’m curious if anybody else has seen the same thing, or if you found a dose that doesn’t mess with your stomach. I’ve also wondered if stacking it with coffee is what makes it worse, because that combo feels kinda cursed some mornings.

Comments

• early_scientist: Yeah, I got a similar thing with NR, especially if I tried it first thing in the morning before breakfast. For me, it wasnt nausea so much as this weird hollow feeling in my gut, almost like too much coffee but without the buzz. I also found that taking it with food, especially something with protein or fat like eggs, seemed to blunt that effect a lot. Im with you on not seeing any big changes in sleep or mood, though. Definitely not some night and day energy jump, at least for me. When I tried
• amber464: Yep, that hollow feeling is a good way to put it, that’s basically what I meant by “tight, off.” Mine was most obvious on a near-empty stomach around 500 mg, and coffee on top of it was basically a nope. Eggs helped the most for me too, yogurt was second best. I’m not seeing much beyond maybe a tiny alertness bump either, and even that’s fuzzy. How far apart were you spacing NR and coffee when you noticed it, same time or within an hour?
• aspiring_trailrun: Pretty much the same for me, coffee too close seemed to make the stomach stuff more obvious. If I left at least an hour and had food in me, it was usually fine. On an empty stomach with coffee, it felt a bit dodgy 😎
• engineer_dan: Yep, same vibe here basically. NR on an empty stomach plus coffee felt pretty rough for me too, like my gut was complaining before anything else. With food, it’s way more tolerable. Could just be sensitivity, but that timing seems to matter a lot.
• greg_codes: yeah nah, the coffee combo is a disaster? ngl i tried that and my hrv tanked for two days. felt like my system was just too wired? definitely seems like the stomach stuff is common. i just stick to it with a proper breakfast now. sweet as if that works for you too?
• amber464: yeah, same here – coffee + NR sent my HRV down like a cliff for a couple nights. I’ve been doing 500 mg with a bowl of oatmeal and a splash of almond milk, and the nausea disappears. My morning HRV stays within 2‑3 ms of baseline, unlike the coffee mix. Glad you’re sticking to a solid breakfast; any tweak to the carbs (like swapping to toast) makes a difference for me. Do you notice any change in how quickly the alertness fades after the meal?
• amber464: that confirms it imo. i tried the coffee combo once and it felt like my stomach was just twisting. i'm gonna try sticking to that hour gap you mentioned and see if it helps. i wonder if the acidity of the coffee just hits harder when the nr is already irritating the lining. did you find that the timing mattered more for the nausea or just that general dodgy feeling?

Community discussion - research and educational context only. Not medical advice.