Epithalon vs Klotho
A side-by-side research comparison of Epithalon and Klotho across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | Klotho |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Klotho Protein |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Research compound (preclinical/early) |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | Exists in membrane-bound and soluble forms. Soluble Klotho acts as a circulating hormone that modulates FGF23 signaling, regulates phosphate/vitamin D balance, suppresses certain growth and oxidative-stress pathways, and supports synaptic and cognitive function. |
| Molecular weight | 390.4 Da | ~130 kDa (full protein; fragments studied) |
| Half-life | 3-4 hours | Not well established for therapeutic forms |
| Bioavailability | High (SubQ) | Injectable in research; large protein with limited oral absorption |
| Typical dose | 5-10 mg | No established human dose |
| Frequency | Daily for 10-20 days | Unknown |
| Route | Subcutaneous injection | Injection (research) |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
Klotho reported benefits
- Associated with longevity and slower aging
- Neuroprotection and improved cognition (preclinical)
- Supports kidney and cardiovascular health
- Regulates phosphate and mineral balance
Related comparisons
Research and educational reference only. Not medical advice.