Klotho (Klotho Protein)
A longevity-associated protein named after the Greek Fate who spins the thread of life. Higher Klotho levels are linked to slower aging, better cognition, and kidney and cardiovascular health. Studied for neuroprotection and age-related decline.
How it works
Exists in membrane-bound and soluble forms. Soluble Klotho acts as a circulating hormone that modulates FGF23 signaling, regulates phosphate/vitamin D balance, suppresses certain growth and oxidative-stress pathways, and supports synaptic and cognitive function.
Key facts
- Molecular weight: ~130 kDa (full protein; fragments studied)
- Half-life: Not well established for therapeutic forms
- Bioavailability: Injectable in research; large protein with limited oral absorption
- Storage: Protein material kept frozen/refrigerated per supplier guidance; avoid freeze-thaw cycles.
Dosing overview
- Typical dose: No established human dose
- Frequency: Unknown
- Duration: Unknown
- Route: Injection (research)
Protocol notes
- No validated human protocol exists; data are largely preclinical.
- Animal studies have used injected soluble Klotho or fragments.
- Any human use should be considered experimental.
Reported benefits
- Associated with longevity and slower aging
- Neuroprotection and improved cognition (preclinical)
- Supports kidney and cardiovascular health
- Regulates phosphate and mineral balance
Possible side effects
- Human safety unknown
- No established side-effect profile
- Mineral/phosphate regulation effects are unstudied in supplementation
Research
- Klotho and cognitive enhancement (2014): Elevating Klotho improved synaptic function and cognition in mouse models.
- Klotho as a longevity hormone (2018): Reviewed associations between higher Klotho and reduced age-related disease and mortality.
Compare Klotho
Research and educational reference only. Not medical advice.