Epithalon vs GDF-11
A side-by-side research comparison of Epithalon and GDF-11 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | GDF-11 |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Growth Differentiation Factor 11 |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Research compound |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. |
| Molecular weight | 390.4 Da | 12,500 Da |
| Half-life | 3-4 hours | 6-8 hours |
| Bioavailability | High (SubQ) | Moderate (SubQ/IV) |
| Typical dose | 5-10 mg | 0.1-0.5 mg/kg (research) |
| Frequency | Daily for 10-20 days | Daily (animal studies) |
| Route | Subcutaneous injection | Subcutaneous |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
Related comparisons
Research and educational reference only. Not medical advice.