Epithalon vs NAD+
A side-by-side research comparison of Epithalon and NAD+ across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | NAD+ |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Nicotinamide Adenine Dinucleotide (NAD+ / NMN / NR) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Research compound |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | NAD+ serves as cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Declining NAD+ impairs mitochondrial function and epigenetic maintenance. Restoration reactivates longevity pathways. |
| Molecular weight | 390.4 Da | 663.4 Da |
| Half-life | 3-4 hours | 1-4 hours (IV), 4-8h (oral precursors) |
| Bioavailability | High (SubQ) | 100% (IV), variable (oral 5-30%) |
| Typical dose | 5-10 mg | 250-500mg IV or 500-1000mg NMN oral |
| Frequency | Daily for 10-20 days | Weekly (IV) or Daily (oral) |
| Route | Subcutaneous injection | IV infusion or Oral (precursors) |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
NAD+ reported benefits
- Restored cellular energy
- Enhanced DNA repair
- Sirtuin activation
- Improved mitochondrial function
- Cognitive clarity
- Anti-aging
Related comparisons
Research and educational reference only. Not medical advice.