Epithalon vs Fisetin
A side-by-side research comparison of Epithalon and Fisetin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | Fisetin |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Fisetin (Senolytic Flavonoid) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Dietary compound (research ongoing) |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity. |
| Molecular weight | 390.4 Da | 286.24 Da |
| Half-life | 3-4 hours | Short; poor baseline absorption (often taken with fat) |
| Bioavailability | High (SubQ) | Low oral; improved with lipids/liposomal forms |
| Typical dose | 5-10 mg | ~20 mg/kg on hit days (protocol-dependent) |
| Frequency | Daily for 10-20 days | Intermittent "hit and run" courses |
| Route | Subcutaneous injection | Oral |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
Fisetin reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Studied for healthspan extension
- Neuroprotective signals in research
Related comparisons
Research and educational reference only. Not medical advice.