Fisetin (Fisetin (Senolytic Flavonoid))
A plant flavonoid found in strawberries, apples, and onions, studied as a senolytic - an agent that selectively clears senescent ("zombie") cells that accumulate with age and drive inflammation.
How it works
Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity.
Key facts
- Molecular weight: 286.24 Da
- Half-life: Short; poor baseline absorption (often taken with fat)
- Bioavailability: Low oral; improved with lipids/liposomal forms
- Storage: Keep cool, dry, and sealed; protect from light.
Dosing overview
- Typical dose: ~20 mg/kg on hit days (protocol-dependent)
- Frequency: Intermittent "hit and run" courses
- Duration: 2-3 consecutive days, repeated periodically
- Route: Oral
Protocol notes
- A common longevity protocol uses high-dose "hit days" (e.g. 2-3 consecutive days) every few weeks or months, rather than daily use.
- Often taken with a fatty meal or in a liposomal form to improve absorption.
- Lower daily maintenance doses are also used for general antioxidant support.
Reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Studied for healthspan extension
- Neuroprotective signals in research
Possible side effects
- Generally well tolerated
- Mild GI upset at high doses
- Long-term human senolytic data limited
Research
- Fisetin as a senotherapeutic (2018): Reduced senescent cell burden and extended healthspan/lifespan in aged mice.
Compare Fisetin
Research and educational reference only. Not medical advice.