Epithalon vs Metformin
A side-by-side research comparison of Epithalon and Metformin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Epithalon | Metformin |
|---|---|---|
| Full name | Epithalon (Epitalon / Epithalone) | Metformin Hydrochloride |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | FDA-approved (off-label for longevity) |
| Mechanism | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. | Activates AMP-activated protein kinase (AMPK), inhibits mitochondrial complex I, reduces hepatic glucose output, and activates autophagy. Mimics the metabolic benefits of caloric restriction. |
| Molecular weight | 390.4 Da | 165.62 Da |
| Half-life | 3-4 hours | ~6.2 hours |
| Bioavailability | High (SubQ) | ~50-60% oral |
| Typical dose | 5-10 mg | 500-1000 mg |
| Frequency | Daily for 10-20 days | 1-2x daily |
| Route | Subcutaneous injection | Oral tablet (extended-release preferred) |
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
Metformin reported benefits
- AMPK activation
- Anti-aging cellular effects
- Cancer risk reduction
- Cardiovascular protection
- Blood sugar regulation
- Longevity support
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Research and educational reference only. Not medical advice.