Cortexin vs Semax
A side-by-side research comparison of Cortexin and Semax across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortexin | Semax |
|---|---|---|
| Full name | Cortexin (Polypeptide Brain Extract) | Semax (ACTH 4-10 analog) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound (used clinically in some regions) | Research compound |
| Mechanism | Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair. | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. |
| Molecular weight | Mixture (peptides <10 kDa) | 813.9 Da |
| Half-life | Varies by component | 3-5 min (systemic) / extended (intranasal) |
| Bioavailability | Intramuscular injection | Moderate (intranasal) |
| Typical dose | ~10 mg per day (course-based) | 200-600 mcg per dose |
| Frequency | Once daily | 2-3x daily |
| Route | Intramuscular injection | Intranasal drops/spray |
Cortexin reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Related comparisons
Research and educational reference only. Not medical advice.