Cortexin vs FGL
A side-by-side research comparison of Cortexin and FGL across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortexin | FGL |
|---|---|---|
| Full name | Cortexin (Polypeptide Brain Extract) | FGL (NCAM-Derived Peptide) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound (used clinically in some regions) | Research compound |
| Mechanism | Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair. | Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement. |
| Molecular weight | Mixture (peptides <10 kDa) | ~1,800 Da |
| Half-life | Varies by component | 4-8 hours |
| Bioavailability | Intramuscular injection | Moderate (SubQ, partial BBB crossing) |
| Typical dose | ~10 mg per day (course-based) | 1-5 mg/kg (research) |
| Frequency | Once daily | Daily or every other day |
| Route | Intramuscular injection | Subcutaneous |
Cortexin reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
FGL reported benefits
- Synaptic plasticity
- LTP facilitation
- Memory improvement
- Neurotrophic effects
- FGFR activation
Related comparisons
Research and educational reference only. Not medical advice.