Cortexin (Cortexin (Polypeptide Brain Extract))
A mixture of low-molecular-weight neuropeptides derived from cattle/pig cerebral cortex, used in some countries for neuroprotection, recovery after stroke or brain injury, and cognitive support.
How it works
Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair.
Key facts
- Molecular weight: Mixture (peptides <10 kDa)
- Half-life: Varies by component
- Bioavailability: Intramuscular injection
- Storage: Lyophilized: refrigerate. Reconstituted: use promptly per label.
Dosing overview
- Typical dose: ~10 mg per day (course-based)
- Frequency: Once daily
- Duration: 10-day courses, repeatable
- Route: Intramuscular injection
Protocol notes
- Typically administered as a ~10-day course of once-daily intramuscular injections.
- Courses may be repeated a few times per year.
- Used in some regions for recovery after brain injury or for cognitive support.
Reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
Possible side effects
- Injection site reactions
- Allergic reaction (animal-derived)
- Limited Western clinical data
Research
- Cortexin in cognitive recovery (2017): Reported improvements in cognitive recovery after ischemic stroke in regional clinical studies.
Compare Cortexin
Research and educational reference only. Not medical advice.