Cerebrolysin vs Cortexin
A side-by-side research comparison of Cerebrolysin and Cortexin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cerebrolysin | Cortexin |
|---|---|---|
| Full name | Cerebrolysin (Brain-Derived Peptide Preparation) | Cortexin (Polypeptide Brain Extract) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Investigational | Research compound (used clinically in some regions) |
| Mechanism | Contains fragments mimicking NGF, BDNF, GDNF, CNTF. Enhances synaptic plasticity, promotes neuronal sprouting, reduces amyloid-beta, and stabilizes calcium homeostasis. | Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair. |
| Molecular weight | <10,000 Da (peptide fraction) | Mixture (peptides <10 kDa) |
| Half-life | 4-6 hours | Varies by component |
| Bioavailability | High (IM/IV) | Intramuscular injection |
| Typical dose | 5-30 mL | ~10 mg per day (course-based) |
| Frequency | Daily for 10-20 days | Once daily |
| Route | Intramuscular or IV | Intramuscular injection |
Cerebrolysin reported benefits
- Neurotrophic support
- Stroke recovery
- Memory improvement
- Neuroprotection
- Synaptic plasticity
- Approved in 40+ countries
Cortexin reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
Related comparisons
Research and educational reference only. Not medical advice.