Cortexin vs NSI-189
A side-by-side research comparison of Cortexin and NSI-189 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortexin | NSI-189 |
|---|---|---|
| Full name | Cortexin (Polypeptide Brain Extract) | NSI-189 Phosphate (Neurogenic Compound) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound (used clinically in some regions) | Investigational |
| Mechanism | Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair. | Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI. |
| Molecular weight | Mixture (peptides <10 kDa) | 366.4 Da |
| Half-life | Varies by component | 18-22 hours |
| Bioavailability | Intramuscular injection | High (oral) |
| Typical dose | ~10 mg per day (course-based) | 40-80 mg |
| Frequency | Once daily | Once daily |
| Route | Intramuscular injection | Oral |
Cortexin reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
NSI-189 reported benefits
- Hippocampal neurogenesis
- Measurable brain volume increase
- Cognitive enhancement
- Antidepressant effects
- Long-term neural benefit
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Research and educational reference only. Not medical advice.