Cortexin vs Dihexa
A side-by-side research comparison of Cortexin and Dihexa across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortexin | Dihexa |
|---|---|---|
| Full name | Cortexin (Polypeptide Brain Extract) | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound (used clinically in some regions) | Research compound |
| Mechanism | Provides a blend of neuropeptides and neurotrophic factors thought to support neuronal metabolism, reduce oxidative stress, balance excitatory/inhibitory neurotransmission, and promote neuroprotection and repair. | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. |
| Molecular weight | Mixture (peptides <10 kDa) | 507.6 Da |
| Half-life | Varies by component | 6-12 hours |
| Bioavailability | Intramuscular injection | Moderate (oral/SubQ) |
| Typical dose | ~10 mg per day (course-based) | 10-20 mg (oral) or 2-5 mg (SubQ) |
| Frequency | Once daily | Daily |
| Route | Intramuscular injection | Oral or Subcutaneous |
Cortexin reported benefits
- Neuroprotection
- Cognitive and memory support
- Used in stroke/TBI recovery (regional clinical use)
- Antioxidant effects
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
Related comparisons
Research and educational reference only. Not medical advice.