Ca-AKG vs Epithalon
A side-by-side research comparison of Ca-AKG and Epithalon across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ca-AKG | Epithalon |
|---|---|---|
| Full name | Calcium Alpha-Ketoglutarate | Epithalon (Epitalon / Epithalone) |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Research compound |
| Mechanism | Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines. | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. |
| Molecular weight | ~204 Da (AKG portion) | 390.4 Da |
| Half-life | Short; rapidly metabolized | 3-4 hours |
| Bioavailability | Oral | High (SubQ) |
| Typical dose | 1-3 g per day | 5-10 mg |
| Frequency | 1-2x daily | Daily for 10-20 days |
| Route | Oral | Subcutaneous injection |
Ca-AKG reported benefits
- Supports cellular energy metabolism
- Studied for reduced biological-aging markers
- May lower inflammation
- Supports collagen synthesis
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
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Research and educational reference only. Not medical advice.