Ca-AKG (Calcium Alpha-Ketoglutarate)
A calcium salt of alpha-ketoglutarate, a metabolite central to the Krebs cycle that declines with age. Popular in longevity circles for potential effects on biological aging markers, inflammation, and healthspan.
How it works
Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines.
Key facts
- Molecular weight: ~204 Da (AKG portion)
- Half-life: Short; rapidly metabolized
- Bioavailability: Oral
- Storage: Keep cool, dry, and sealed.
Dosing overview
- Typical dose: 1-3 g per day
- Frequency: 1-2x daily
- Duration: Ongoing
- Route: Oral
Protocol notes
- Common range is ~1-3 g daily, sometimes split into two doses.
- Taken with or without food.
- Used continuously as a longevity supplement.
Reported benefits
- Supports cellular energy metabolism
- Studied for reduced biological-aging markers
- May lower inflammation
- Supports collagen synthesis
Possible side effects
- Generally well tolerated
- Mild GI upset at higher doses
Research
- Alpha-ketoglutarate and biological age markers (2021): An observational study reported reductions in a DNA-methylation biological age measure with AKG supplementation.
Compare Ca-AKG
Research and educational reference only. Not medical advice.