Ca-AKG vs GDF-11
A side-by-side research comparison of Ca-AKG and GDF-11 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ca-AKG | GDF-11 |
|---|---|---|
| Full name | Calcium Alpha-Ketoglutarate | Growth Differentiation Factor 11 |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Research compound |
| Mechanism | Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines. | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. |
| Molecular weight | ~204 Da (AKG portion) | 12,500 Da |
| Half-life | Short; rapidly metabolized | 6-8 hours |
| Bioavailability | Oral | Moderate (SubQ/IV) |
| Typical dose | 1-3 g per day | 0.1-0.5 mg/kg (research) |
| Frequency | 1-2x daily | Daily (animal studies) |
| Route | Oral | Subcutaneous |
Ca-AKG reported benefits
- Supports cellular energy metabolism
- Studied for reduced biological-aging markers
- May lower inflammation
- Supports collagen synthesis
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
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Research and educational reference only. Not medical advice.