Ca-AKG vs SS-31 (Elamipretide)
A side-by-side research comparison of Ca-AKG and SS-31 (Elamipretide) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ca-AKG | SS-31 (Elamipretide) |
|---|---|---|
| Full name | Calcium Alpha-Ketoglutarate | SS-31 / Elamipretide (Bendavia) |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Investigational |
| Mechanism | Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines. | Targets cardiolipin in inner mitochondrial membrane, stabilizes cytochrome c binding, optimizes electron transfer efficiency, and reduces mitochondrial ROS by 50%. |
| Molecular weight | ~204 Da (AKG portion) | 640.8 Da |
| Half-life | Short; rapidly metabolized | 4-6 hours |
| Bioavailability | Oral | High (SubQ) |
| Typical dose | 1-3 g per day | 5-40 mg |
| Frequency | 1-2x daily | Daily |
| Route | Oral | Subcutaneous or IV |
Ca-AKG reported benefits
- Supports cellular energy metabolism
- Studied for reduced biological-aging markers
- May lower inflammation
- Supports collagen synthesis
SS-31 (Elamipretide) reported benefits
- Mitochondrial function optimization
- Reduced oxidative stress
- Cardioprotection
- Improved exercise capacity
- Renal protection
- Cellular energy
Related comparisons
Research and educational reference only. Not medical advice.