Ca-AKG vs Humanin
A side-by-side research comparison of Ca-AKG and Humanin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ca-AKG | Humanin |
|---|---|---|
| Full name | Calcium Alpha-Ketoglutarate | Humanin (HN) Mitochondrial-Derived Peptide |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Research compound |
| Mechanism | Alpha-ketoglutarate is a key TCA-cycle intermediate and a cofactor for enzymes involved in energy metabolism, collagen synthesis, and epigenetic regulation (it influences DNA/histone demethylases). Supplementation aims to restore age-related declines. | Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection. |
| Molecular weight | ~204 Da (AKG portion) | 2,687 Da |
| Half-life | Short; rapidly metabolized | 4-6 hours |
| Bioavailability | Oral | Moderate (SubQ) |
| Typical dose | 1-3 g per day | 1-5 mg |
| Frequency | 1-2x daily | 3-5x per week |
| Route | Oral | Subcutaneous |
Ca-AKG reported benefits
- Supports cellular energy metabolism
- Studied for reduced biological-aging markers
- May lower inflammation
- Supports collagen synthesis
Humanin reported benefits
- Neuroprotection against amyloid-beta
- Anti-apoptotic
- Improved insulin sensitivity
- Cardioprotection
- Cellular stress resistance
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Research and educational reference only. Not medical advice.