N-Acetyl Semax Amidate vs Semax
A side-by-side research comparison of N-Acetyl Semax Amidate and Semax across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Semax Amidate | Semax |
|---|---|---|
| Full name | N-Acetyl Semax Amidate (NA Semax) | Semax (ACTH 4-10 analog) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | A heptapeptide analog of ACTH(4-10) that increases BDNF and NGF expression, modulates the dopaminergic and serotonergic systems, and provides neuroprotective and pro-focus effects. The acetyl/amidate modifications extend its half-life versus plain Semax. | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. |
| Molecular weight | ~900 Da | 813.9 Da |
| Half-life | Longer than base Semax (modifications resist peptidases) | 3-5 min (systemic) / extended (intranasal) |
| Bioavailability | Intranasal (primary); subcutaneous also used | Moderate (intranasal) |
| Typical dose | ~300-600 mcg per day | 200-600 mcg per dose |
| Frequency | 1-2x daily | 2-3x daily |
| Route | Intranasal spray/drops | Intranasal drops/spray |
N-Acetyl Semax Amidate reported benefits
- Improved focus and mental clarity
- Raises BDNF/NGF (neurotrophic)
- Neuroprotective
- Longer-acting than base Semax
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Related comparisons
Research and educational reference only. Not medical advice.