N-Acetyl Semax Amidate vs P21
A side-by-side research comparison of N-Acetyl Semax Amidate and P21 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Semax Amidate | P21 |
|---|---|---|
| Full name | N-Acetyl Semax Amidate (NA Semax) | P21 (CNTF-Derived Tetrapeptide) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | A heptapeptide analog of ACTH(4-10) that increases BDNF and NGF expression, modulates the dopaminergic and serotonergic systems, and provides neuroprotective and pro-focus effects. The acetyl/amidate modifications extend its half-life versus plain Semax. | Mimics CNTF neurogenesis-enhancing portion by increasing BDNF and activating PI3K/Akt. Inhibits LIF signaling to selectively promote neural stem cell proliferation. |
| Molecular weight | ~900 Da | ~450 Da |
| Half-life | Longer than base Semax (modifications resist peptidases) | 4-6 hours |
| Bioavailability | Intranasal (primary); subcutaneous also used | Moderate (crosses BBB) |
| Typical dose | ~300-600 mcg per day | 50-100 mcg/kg |
| Frequency | 1-2x daily | Daily |
| Route | Intranasal spray/drops | Intranasal or Subcutaneous |
N-Acetyl Semax Amidate reported benefits
- Improved focus and mental clarity
- Raises BDNF/NGF (neurotrophic)
- Neuroprotective
- Longer-acting than base Semax
P21 reported benefits
- Hippocampal neurogenesis
- BDNF increase
- Cognitive enhancement
- BBB penetrant
- No appetite suppression
- Dendritic branching
Related comparisons
Research and educational reference only. Not medical advice.