N-Acetyl Semax Amidate vs NSI-189
A side-by-side research comparison of N-Acetyl Semax Amidate and NSI-189 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Semax Amidate | NSI-189 |
|---|---|---|
| Full name | N-Acetyl Semax Amidate (NA Semax) | NSI-189 Phosphate (Neurogenic Compound) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Investigational |
| Mechanism | A heptapeptide analog of ACTH(4-10) that increases BDNF and NGF expression, modulates the dopaminergic and serotonergic systems, and provides neuroprotective and pro-focus effects. The acetyl/amidate modifications extend its half-life versus plain Semax. | Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI. |
| Molecular weight | ~900 Da | 366.4 Da |
| Half-life | Longer than base Semax (modifications resist peptidases) | 18-22 hours |
| Bioavailability | Intranasal (primary); subcutaneous also used | High (oral) |
| Typical dose | ~300-600 mcg per day | 40-80 mg |
| Frequency | 1-2x daily | Once daily |
| Route | Intranasal spray/drops | Oral |
N-Acetyl Semax Amidate reported benefits
- Improved focus and mental clarity
- Raises BDNF/NGF (neurotrophic)
- Neuroprotective
- Longer-acting than base Semax
NSI-189 reported benefits
- Hippocampal neurogenesis
- Measurable brain volume increase
- Cognitive enhancement
- Antidepressant effects
- Long-term neural benefit
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Research and educational reference only. Not medical advice.