N-Acetyl Semax Amidate vs Selank
A side-by-side research comparison of N-Acetyl Semax Amidate and Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Semax Amidate | Selank |
|---|---|---|
| Full name | N-Acetyl Semax Amidate (NA Semax) | Selank (TP-7) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | A heptapeptide analog of ACTH(4-10) that increases BDNF and NGF expression, modulates the dopaminergic and serotonergic systems, and provides neuroprotective and pro-focus effects. The acetyl/amidate modifications extend its half-life versus plain Semax. | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. |
| Molecular weight | ~900 Da | 751.9 Da |
| Half-life | Longer than base Semax (modifications resist peptidases) | 3-5 min (IV) / 15-30 min (intranasal) |
| Bioavailability | Intranasal (primary); subcutaneous also used | Moderate (intranasal) |
| Typical dose | ~300-600 mcg per day | 250-750 mcg per spray dose |
| Frequency | 1-2x daily | 2-3x daily |
| Route | Intranasal spray/drops | Intranasal spray |
N-Acetyl Semax Amidate reported benefits
- Improved focus and mental clarity
- Raises BDNF/NGF (neurotrophic)
- Neuroprotective
- Longer-acting than base Semax
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Related comparisons
Research and educational reference only. Not medical advice.