MGF (Mechano Growth Factor) vs YK-11
A side-by-side research comparison of MGF (Mechano Growth Factor) and YK-11 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | MGF (Mechano Growth Factor) | YK-11 |
|---|---|---|
| Full name | Mechano Growth Factor (IGF-1Ec splice variant) | YK-11 (Myostatin Inhibitor / SARM) |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Research compound |
| Mechanism | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. | Partial androgen receptor agonist that induces follistatin expression, creating dual myostatin inhibition and AR activation. |
| Molecular weight | 2,867 Da (synthetic fragment) | 430.54 Da |
| Half-life | 5-7 min (native) / 24-48h (PEGylated) | ~6-10 hours |
| Bioavailability | High (local IM) | ~70% oral |
| Typical dose | 100-200 mcg PEG-MGF | 5-10 mg |
| Frequency | 2-3x per week | Once daily |
| Route | Intramuscular (local) | Oral |
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
YK-11 reported benefits
- Dual anabolic mechanism
- Follistatin induction
- Oral convenience
- Muscle hardening
Related comparisons
Research and educational reference only. Not medical advice.