IGF-1 LR3 vs MGF (Mechano Growth Factor)
A side-by-side research comparison of IGF-1 LR3 and MGF (Mechano Growth Factor) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | IGF-1 LR3 | MGF (Mechano Growth Factor) |
|---|---|---|
| Full name | Insulin-like Growth Factor-1 Long R3 | Mechano Growth Factor (IGF-1Ec splice variant) |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Research compound |
| Mechanism | Activates IGF-1R while evading IGFBP sequestration. Triggers PI3K/Akt/mTOR for protein synthesis, satellite cell proliferation, and amino acid uptake into muscle. | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. |
| Molecular weight | 9,111 Da | 2,867 Da (synthetic fragment) |
| Half-life | 20-30 hours (vs 15 min native) | 5-7 min (native) / 24-48h (PEGylated) |
| Bioavailability | High (SubQ/IM) | High (local IM) |
| Typical dose | 20-50 mcg | 100-200 mcg PEG-MGF |
| Frequency | Daily (post-workout) | 2-3x per week |
| Route | Subcutaneous or intramuscular injection | Intramuscular (local) |
IGF-1 LR3 reported benefits
- Potent anabolic effects
- Hyperplasia (new muscle cells)
- Extended half-life
- Enhanced recovery
- Improved nutrient partitioning
- Satellite cell activation
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
Related comparisons
Research and educational reference only. Not medical advice.