ACE-031 vs MGF (Mechano Growth Factor)
A side-by-side research comparison of ACE-031 and MGF (Mechano Growth Factor) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | ACE-031 | MGF (Mechano Growth Factor) |
|---|---|---|
| Full name | ACE-031 (Soluble ActRIIB-Fc Fusion) | Mechano Growth Factor (IGF-1Ec splice variant) |
| Category | Muscle Growth | Muscle Growth |
| Status | Investigational | Research compound |
| Mechanism | Decoy receptor sequestering TGF-B ligands (myostatin, activin, GDF-11) in bloodstream, preventing cell-surface ActRIIB binding and removing multiple anabolic brakes. | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. |
| Molecular weight | ~90,000 Da | 2,867 Da (synthetic fragment) |
| Half-life | 10-14 days | 5-7 min (native) / 24-48h (PEGylated) |
| Bioavailability | High (SubQ) | High (local IM) |
| Typical dose | 0.3-3 mg/kg | 100-200 mcg PEG-MGF |
| Frequency | Every 2-4 weeks | 2-3x per week |
| Route | Subcutaneous | Intramuscular (local) |
ACE-031 reported benefits
- Multi-ligand pathway inhibition
- Lean mass increase
- Bone density increase
- Infrequent dosing
- Functional strength improvement
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
Related comparisons
Research and educational reference only. Not medical advice.