Follistatin 344 vs MGF (Mechano Growth Factor)
A side-by-side research comparison of Follistatin 344 and MGF (Mechano Growth Factor) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Follistatin 344 | MGF (Mechano Growth Factor) |
|---|---|---|
| Full name | Follistatin 344 (FST-344) | Mechano Growth Factor (IGF-1Ec splice variant) |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Research compound |
| Mechanism | Binds myostatin and activin A with high affinity, preventing ActRIIB receptor activation. Removes the brake on muscle growth allowing uninhibited satellite cell proliferation. | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. |
| Molecular weight | 36,000 Da | 2,867 Da (synthetic fragment) |
| Half-life | 2-4 hours | 5-7 min (native) / 24-48h (PEGylated) |
| Bioavailability | Moderate (SubQ) | High (local IM) |
| Typical dose | 100-200 mcg | 100-200 mcg PEG-MGF |
| Frequency | Daily for 10-30 days | 2-3x per week |
| Route | Subcutaneous | Intramuscular (local) |
Follistatin 344 reported benefits
- Significant muscle growth
- Myostatin inhibition
- Increased strength
- Activin neutralization
- Enhanced recovery
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
Related comparisons
Research and educational reference only. Not medical advice.