MGF (Mechano Growth Factor) vs PEG-MGF
A side-by-side research comparison of MGF (Mechano Growth Factor) and PEG-MGF across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | MGF (Mechano Growth Factor) | PEG-MGF |
|---|---|---|
| Full name | Mechano Growth Factor (IGF-1Ec splice variant) | PEGylated Mechano Growth Factor |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Research compound |
| Mechanism | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. | PEGylation protects MGF from rapid degradation, extending half-life from minutes to hours. Activates satellite cells systemically for whole-body muscle recovery. |
| Molecular weight | 2,867 Da (synthetic fragment) | ~5000 Da (with PEG) |
| Half-life | 5-7 min (native) / 24-48h (PEGylated) | ~30 minutes to several hours (vs 5-7 min native) |
| Bioavailability | High (local IM) | ~85% subcutaneous |
| Typical dose | 100-200 mcg PEG-MGF | 100-200 mcg |
| Frequency | 2-3x per week | 2-3x per week |
| Route | Intramuscular (local) | Subcutaneous injection |
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
PEG-MGF reported benefits
- Extended half-life vs native MGF
- Systemic satellite cell activation
- Whole-body recovery
- Less frequent dosing
Related comparisons
Research and educational reference only. Not medical advice.