Pinealon (Pinealon (Glu-Asp-Arg))
A short synthetic tripeptide (Glu-Asp-Arg) from the bioregulator family studied in Russia. Investigated for neuroprotection, antioxidant effects, and support of brain function during aging and oxidative stress.
How it works
As a peptide bioregulator it is proposed to penetrate cells and interact with DNA to modulate gene expression in neural tissue, reducing oxidative damage and supporting neuronal survival and protein synthesis.
Key facts
- Molecular weight: ~418 Da
- Half-life: Short (small peptide, rapidly metabolized)
- Bioavailability: Injectable in research; intranasal also used
- Storage: Lyophilized: refrigerate. Reconstituted: 2-8°C, use within ~2 weeks.
Dosing overview
- Typical dose: ~5-10 mg per course day (research)
- Frequency: Daily during a short course
- Duration: 10-20 day courses
- Route: Subcutaneous or intranasal
Protocol notes
- Bioregulator courses are typically short (about 10-20 days) and repeated a few times per year.
- Often run alongside other Khavinson-type peptide bioregulators.
- Doses are small given the low molecular weight.
Reported benefits
- Neuroprotective and antioxidant effects (research)
- Supports cognition under stress/aging
- May support healthy sleep-wake regulation
- Short-course bioregulator profile
Possible side effects
- Limited human safety data
- Mild injection site reactions
- Generally reported as well tolerated in small studies
Research
- Pinealon and protection against oxidative stress (2013): Reduced markers of oxidative damage and supported neuronal survival in cell and animal models.
- Short peptides in neuronal protein synthesis (2015): Reported modulation of neuronal gene expression and protein synthesis by Glu-Asp-Arg.
Compare Pinealon
Community discussions about Pinealon
- New Russian Pinealon trial claims cognitive boost in older adults – too good to be true? - 4 comments
- Ask the community about Pinealon
Research and educational reference only. Not medical advice.