NSI-189 vs Pinealon
A side-by-side research comparison of NSI-189 and Pinealon across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | NSI-189 | Pinealon |
|---|---|---|
| Full name | NSI-189 Phosphate (Neurogenic Compound) | Pinealon (Glu-Asp-Arg) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Investigational | Research compound |
| Mechanism | Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI. | As a peptide bioregulator it is proposed to penetrate cells and interact with DNA to modulate gene expression in neural tissue, reducing oxidative damage and supporting neuronal survival and protein synthesis. |
| Molecular weight | 366.4 Da | ~418 Da |
| Half-life | 18-22 hours | Short (small peptide, rapidly metabolized) |
| Bioavailability | High (oral) | Injectable in research; intranasal also used |
| Typical dose | 40-80 mg | ~5-10 mg per course day (research) |
| Frequency | Once daily | Daily during a short course |
| Route | Oral | Subcutaneous or intranasal |
NSI-189 reported benefits
- Hippocampal neurogenesis
- Measurable brain volume increase
- Cognitive enhancement
- Antidepressant effects
- Long-term neural benefit
Pinealon reported benefits
- Neuroprotective and antioxidant effects (research)
- Supports cognition under stress/aging
- May support healthy sleep-wake regulation
- Short-course bioregulator profile
Related comparisons
Research and educational reference only. Not medical advice.