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N-Acetyl Selank Amidate (N-Acetyl Selank Amidate (NA Selank))

Category: Cognitive & Nootropic. Status: Research compound.

A stabilized, longer-acting version of Selank, an anxiolytic nootropic derived from the immune peptide tuftsin. Used intranasally for calm focus, anxiety reduction, and mood support without sedation or dependence.

How it works

Modulates GABA and serotonin systems and influences BDNF and the expression of enkephalin-degrading enzymes, producing anti-anxiety and mood-stabilizing effects. The acetyl/amidate modifications extend its duration.

Key facts

  • Molecular weight: ~800 Da
  • Half-life: Longer than base Selank
  • Bioavailability: Intranasal (primary); subcutaneous also used
  • Storage: Refrigerate (2-8°C); keep nasal solutions cold and use within the labeled window.

Dosing overview

  • Typical dose: ~300-900 mcg per day
  • Frequency: 1-2x daily
  • Duration: As needed or short courses
  • Route: Intranasal spray/drops

Protocol notes

  • Common use is a few hundred mcg intranasally, 1-2x daily or as needed for anxiety.
  • Non-sedating, so it can be used during the day.
  • Frequently paired with Semax for combined calm-and-focus effects.

Reported benefits

  • Reduces anxiety without sedation
  • Calm focus
  • Mood support
  • No reported dependence/withdrawal

Possible side effects

  • Nasal irritation
  • Mild drowsiness in some
  • Headache (uncommon)

Research

  • Selank anxiolytic effects (2015): Demonstrated anxiety-reducing effects comparable to benzodiazepines without sedation or dependence in studies.

Compare N-Acetyl Selank Amidate

Research and educational reference only. Not medical advice.