N-Acetyl Selank Amidate vs Semax
A side-by-side research comparison of N-Acetyl Selank Amidate and Semax across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Selank Amidate | Semax |
|---|---|---|
| Full name | N-Acetyl Selank Amidate (NA Selank) | Semax (ACTH 4-10 analog) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Modulates GABA and serotonin systems and influences BDNF and the expression of enkephalin-degrading enzymes, producing anti-anxiety and mood-stabilizing effects. The acetyl/amidate modifications extend its duration. | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. |
| Molecular weight | ~800 Da | 813.9 Da |
| Half-life | Longer than base Selank | 3-5 min (systemic) / extended (intranasal) |
| Bioavailability | Intranasal (primary); subcutaneous also used | Moderate (intranasal) |
| Typical dose | ~300-900 mcg per day | 200-600 mcg per dose |
| Frequency | 1-2x daily | 2-3x daily |
| Route | Intranasal spray/drops | Intranasal drops/spray |
N-Acetyl Selank Amidate reported benefits
- Reduces anxiety without sedation
- Calm focus
- Mood support
- No reported dependence/withdrawal
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Related comparisons
Research and educational reference only. Not medical advice.