N-Acetyl Selank Amidate vs P21
A side-by-side research comparison of N-Acetyl Selank Amidate and P21 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | N-Acetyl Selank Amidate | P21 |
|---|---|---|
| Full name | N-Acetyl Selank Amidate (NA Selank) | P21 (CNTF-Derived Tetrapeptide) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Modulates GABA and serotonin systems and influences BDNF and the expression of enkephalin-degrading enzymes, producing anti-anxiety and mood-stabilizing effects. The acetyl/amidate modifications extend its duration. | Mimics CNTF neurogenesis-enhancing portion by increasing BDNF and activating PI3K/Akt. Inhibits LIF signaling to selectively promote neural stem cell proliferation. |
| Molecular weight | ~800 Da | ~450 Da |
| Half-life | Longer than base Selank | 4-6 hours |
| Bioavailability | Intranasal (primary); subcutaneous also used | Moderate (crosses BBB) |
| Typical dose | ~300-900 mcg per day | 50-100 mcg/kg |
| Frequency | 1-2x daily | Daily |
| Route | Intranasal spray/drops | Intranasal or Subcutaneous |
N-Acetyl Selank Amidate reported benefits
- Reduces anxiety without sedation
- Calm focus
- Mood support
- No reported dependence/withdrawal
P21 reported benefits
- Hippocampal neurogenesis
- BDNF increase
- Cognitive enhancement
- BBB penetrant
- No appetite suppression
- Dendritic branching
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Research and educational reference only. Not medical advice.