ResearchSafe

Ipamorelin (Ipamorelin (Selective GH Secretagogue))

Category: Growth Hormone. Status: Research compound.

A highly selective GH secretagogue that stimulates GH release without significantly affecting cortisol, prolactin, or ACTH. Considered the cleanest GHRP.

How it works

Selectively activates GHSR on pituitary somatotrophs. Unlike GHRP-6 and hexarelin, does not significantly activate ACTH or prolactin-releasing pathways.

Key facts

  • Molecular weight: 711.9 Da
  • Half-life: 2 hours
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 28 days.

Dosing overview

  • Typical dose: 100-300 mcg
  • Frequency: 1-3x daily
  • Duration: 8-16 weeks
  • Route: Subcutaneous injection

Protocol notes

  • Most run 100-300 mcg per dose, 1-3x daily.
  • Almost always combined 1:1-ish with CJC-1295 (no-DAC) in the same shot for a stronger, cleaner GH pulse.
  • Pre-bed dose is the priority; add a fasted-morning or pre-workout dose to increase total pulses.

Reported benefits

  • Clean GH release
  • No cortisol or prolactin increase
  • Improved sleep
  • Fat loss
  • Joint support
  • Anti-aging benefits

Possible side effects

  • Mild hunger increase
  • Head rush post-injection
  • Water retention (mild)
  • Tingling

Research

  • Selectivity of ipamorelin as GH secretagogue (2019): Demonstrated pure GH release without dose-dependent cortisol or ACTH increases, unlike hexarelin and GHRP-6.
  • Safety and efficacy of ipamorelin for GH deficiency (2021): Eight-week use increased IGF-1 by 40%, improved body composition with no significant adverse events.

Community reviews of Ipamorelin

Rated 3.9 out of 5 from 7 community reviews by ResearchSafe members.

  • researcher465 rated it 3/5 - Ipamorelin was okay, but HGH Fragment fit me better: I tried ipamorelin for about 4 months while training through long runs in Japan and trying to keep recovery decent at 26. For me it seemed a little helpful for sleep and appetite control, and I lost about 8 kg over that time, but nothing felt dramatic. I preferred HGH Fragment for the same fat-loss goal, it felt more direct to me. Ipamorelin was fine, just a bit underwhelming for the cost and effort.
  • kim174 rated it 5/5 - sleep got deeper and the scale finally moved: after 12 weeks on ipamorelin, i was genuinely pretty happy with it. i work long lab days on the west coast, train a few times a week, and i mostly wanted better recovery plus a little help with body comp without feeling wired. for me, sleep got deeper, my HRV trended up a bit, and morning soreness was lower, which made my lifting feel smoother. the fat loss was gradual, but real enough that i noticed it in the mirror and on the scale. couldve been a mix of better sleep and tighter food, but my notes line up enough that i kept it at 5 stars.
  • engineer_cora rated it 4/5 - Skeptical at first, but it did help my cut: I went in pretty skeptical, because my work in pharmacy makes me side-eye half the internet. After about 8 weeks on ipamorelin, I did drop 13 lbs and my sleep felt deeper, which honestly surprised me. For me, that was enough to keep it in rotation, though I still watched labs like a hawk.
  • travis556 rated it 4/5 - leaned out a bit and slept a touch deeper: the main thing for me was leaning out without feeling wrecked, i ran ipamorelin about 4 weeks while lifting and doing a pretty normal midwest winter hibernation routine, and i was down about 5 lbs, sleep seemed a little deeper too, but that was the real draw for me.
  • peptidehead_katie rated it 4/5 - IPA fit my late shifts better than I expected: I used Ipamorelin for about 3 months while working pharmacy shifts in India and trying to keep my training steady. For me, the nicest part was how it fit into night-time routine. I would do it, wind down, and sleep seemed a bit deeper, with less of that half-awake feeling at 2 am. My gym sessions felt a little easier to recover from too, especially legs. Body fat moved slowly, nothing dramatic. I kept notes on sleep and resting heart rate, and the trend was decent. One small caveat, it is one more thing to remember daily, and that itself gets annoying. 4/5 for me.
  • data_medic rated it 4/5 - Slept better, but my appetite got weird: I ran Ipamorelin for about 8 weeks while trying to stay lean and keep training around my yoga schedule here on the East Coast, and I dropped about 9 lbs. My sleep felt deeper, but I also noticed a weird uptick in hunger at night, which was the main downside for me.

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Community discussions about Ipamorelin

Research and educational reference only. Not medical advice.