Ipamorelin vs MK-677 (Ibutamoren)
A side-by-side research comparison of Ipamorelin and MK-677 (Ibutamoren) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ipamorelin | MK-677 (Ibutamoren) |
|---|---|---|
| Full name | Ipamorelin (Selective GH Secretagogue) | Ibutamoren Mesylate (MK-677) |
| Category | Growth Hormone | Growth Hormone |
| Status | Research compound | Investigational |
| Mechanism | Selectively activates GHSR on pituitary somatotrophs. Unlike GHRP-6 and hexarelin, does not significantly activate ACTH or prolactin-releasing pathways. | Acts as ghrelin mimetic at GHS-R1a receptors in hypothalamus and pituitary. Excellent oral bioavailability and 24-hour duration. |
| Molecular weight | 711.9 Da | 528.7 Da |
| Half-life | 2 hours | 24 hours |
| Bioavailability | High (SubQ) | High (oral) |
| Typical dose | 100-300 mcg | 10-25 mg |
| Frequency | 1-3x daily | Once daily |
| Route | Subcutaneous injection | Oral (capsule/liquid) |
Ipamorelin reported benefits
- Clean GH release
- No cortisol or prolactin increase
- Improved sleep
- Fat loss
- Joint support
- Anti-aging benefits
MK-677 (Ibutamoren) reported benefits
- Oral administration
- Sustained 24h GH elevation
- Increased IGF-1
- Improved sleep depth
- Enhanced recovery
- Bone density support
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Research and educational reference only. Not medical advice.