Fisetin vs NAD+
A side-by-side research comparison of Fisetin and NAD+ across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Fisetin | NAD+ |
|---|---|---|
| Full name | Fisetin (Senolytic Flavonoid) | Nicotinamide Adenine Dinucleotide (NAD+ / NMN / NR) |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Research compound |
| Mechanism | Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity. | NAD+ serves as cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Declining NAD+ impairs mitochondrial function and epigenetic maintenance. Restoration reactivates longevity pathways. |
| Molecular weight | 286.24 Da | 663.4 Da |
| Half-life | Short; poor baseline absorption (often taken with fat) | 1-4 hours (IV), 4-8h (oral precursors) |
| Bioavailability | Low oral; improved with lipids/liposomal forms | 100% (IV), variable (oral 5-30%) |
| Typical dose | ~20 mg/kg on hit days (protocol-dependent) | 250-500mg IV or 500-1000mg NMN oral |
| Frequency | Intermittent "hit and run" courses | Weekly (IV) or Daily (oral) |
| Route | Oral | IV infusion or Oral (precursors) |
Fisetin reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Studied for healthspan extension
- Neuroprotective signals in research
NAD+ reported benefits
- Restored cellular energy
- Enhanced DNA repair
- Sirtuin activation
- Improved mitochondrial function
- Cognitive clarity
- Anti-aging
Related comparisons
Research and educational reference only. Not medical advice.