Fisetin vs GDF-11
A side-by-side research comparison of Fisetin and GDF-11 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Fisetin | GDF-11 |
|---|---|---|
| Full name | Fisetin (Senolytic Flavonoid) | Growth Differentiation Factor 11 |
| Category | Anti-Aging | Anti-Aging |
| Status | Dietary compound (research ongoing) | Research compound |
| Mechanism | Acts as a senolytic by tipping senescent cells toward apoptosis (programmed death) while sparing healthy cells. Also has antioxidant and anti-inflammatory activity. | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. |
| Molecular weight | 286.24 Da | 12,500 Da |
| Half-life | Short; poor baseline absorption (often taken with fat) | 6-8 hours |
| Bioavailability | Low oral; improved with lipids/liposomal forms | Moderate (SubQ/IV) |
| Typical dose | ~20 mg/kg on hit days (protocol-dependent) | 0.1-0.5 mg/kg (research) |
| Frequency | Intermittent "hit and run" courses | Daily (animal studies) |
| Route | Oral | Subcutaneous |
Fisetin reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Studied for healthspan extension
- Neuroprotective signals in research
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
Related comparisons
Research and educational reference only. Not medical advice.