SLU-PP-332 Research Guide

Full name: SLU-PP-332 (ERR Agonist)

An experimental small-molecule "exercise mimetic" that activates estrogen-related receptors (ERRs). In animal studies it increased energy expenditure and endurance and reduced fat gain without changes in food intake or activity, by pushing cells toward fat-burning metabolism.

How SLU-PP-332 Works

A pan-ERR (estrogen-related receptor alpha/beta/gamma) agonist. ERRs are master regulators of mitochondrial biogenesis and oxidative metabolism, so activation upregulates fat oxidation and the genetic program normally triggered by endurance exercise.

Dosing Protocol

• Typical dose: No established human dose
• Frequency: Unknown
• Duration: Unknown
• Route: Injection (preclinical)

Reported Benefits

• Increases mitochondrial fat-burning (preclinical)
• Improved endurance in animals
• Reduced fat gain without appetite change (animals)
• Acts as an "exercise mimetic"

Potential Side Effects

• Human safety unknown
• No human side-effect data
• Potential cardiac/metabolic effects of broad ERR activation are unstudied in people

Research Citations

1. An ERR agonist that mimics aspects of exercise (2023) - In mice, SLU-PP-332 boosted oxidative metabolism, increased running capacity, and limited diet-induced fat gain.

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