Kisspeptin-10 (HPG Axis) Research Guide

Full name: Kisspeptin-10 (Metastin 45-54)

A hypothalamic neuropeptide that is the master upstream regulator of the HPG axis. Stimulates natural GnRH pulsatility to restore endogenous testosterone, LH, and FSH production without suppressing the axis.

How Kisspeptin-10 (HPG Axis) Works

Binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This cascades to LH/FSH secretion from the pituitary, maintaining the natural feedback loop.

Dosing Protocol

• Typical dose: 100-400 mcg
• Frequency: 1-2x daily
• Duration: 4-12 weeks
• Route: Subcutaneous injection

Reported Benefits

• Natural testosterone restoration
• Preserved HPG axis function
• Enhanced libido
• LH/FSH stimulation
• Potential fertility support
• No testicular suppression

Potential Side Effects

• Flushing
• Mild headache
• Injection site irritation
• Nausea (rare)
• Possible tachyphylaxis with continuous use

Research Citations

1. Kisspeptin administration in hypogonadal men (2020) - Single SC injection increased LH by 4.5-fold and testosterone by 2-fold within 4 hours in men with functional hypogonadism.
2. Kisspeptin as HPG axis reset (2022) - Pulsatile kisspeptin-10 restored gonadotropin pulsatility in men with hypothalamic suppression from exogenous androgens.

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