Gonadorelin Research Guide

Full name: Gonadorelin (GnRH Analog)

A synthetic analog of gonadotropin-releasing hormone used diagnostically and therapeutically. Stimulates pulsatile LH and FSH release to maintain natural hormone production.

How Gonadorelin Works

Binds GnRH receptors on pituitary gonadotrophs to stimulate LH and FSH release, maintaining testicular/ovarian function and natural sex hormone production.

Dosing Protocol

• Typical dose: 100-500 mcg
• Frequency: 2-3x per week or pulsatile
• Duration: 4-12 weeks
• Route: Subcutaneous injection

Reported Benefits

• Maintains natural hormone production
• Fertility preservation
• Testicular function support
• LH/FSH normalization

Potential Side Effects

• Injection site reaction
• Headache
• Nausea
• Hot flashes

Research Citations

1. GnRH analogs for fertility preservation (2020) - Maintained spermatogenesis and testicular volume in men using testosterone replacement therapy.
2. Pulsatile GnRH in hypothalamic amenorrhea (2018) - Restored ovulation in 85% of women with functional hypothalamic amenorrhea.

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