Pregnenolone Research Guide

Full name: Pregnenolone (Mother Hormone)

The master precursor hormone from which all steroid hormones are derived. Often called the "mother hormone," it supports cognitive function, mood, and hormonal balance. Popular in telemedicine anti-aging protocols.

How Pregnenolone Works

Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity.

Dosing Protocol

• Typical dose: 50-100 mg
• Frequency: Daily (morning)
• Duration: Ongoing with monitoring
• Route: Oral capsule or sublingual

Reported Benefits

• Hormone precursor balance
• Memory enhancement
• Mood improvement
• Joint support
• Myelin sheath repair
• Stress resilience

Potential Side Effects

• Headache
• Irritability
• Insomnia
• Acne
• Overstimulation

Research Citations

1. Pregnenolone and cognitive performance (2021) - Improved verbal memory and attention scores in adults with low baseline levels over 8-week trial.
2. Neurosteroid replacement in aging (2020) - Restoration of youthful pregnenolone levels correlated with improved sleep architecture and reduced anxiety.

Related Hormone Replacement Compounds

• Gonadorelin - Full Profile
• Enclomiphene - Full Profile
• DHEA - Full Profile
• Liothyronine (T3) - Full Profile
• Anastrozole - Full Profile
• Testosterone Cypionate - Full Profile

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