Dihexa vs NA-Selank
A side-by-side research comparison of Dihexa and NA-Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa | NA-Selank |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) | N-Acetyl Selank (Acetylated Selank) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. | Same tuftsin-derived mechanism as Selank with acetyl group providing protease resistance; modulates GABA, enhances BDNF. |
| Molecular weight | 507.6 Da | 793.91 Da |
| Half-life | 6-12 hours | ~5-10 minutes (effective 4-6 hours) |
| Bioavailability | Moderate (oral/SubQ) | ~95% intranasal |
| Typical dose | 10-20 mg (oral) or 2-5 mg (SubQ) | 200-400 mcg |
| Frequency | Daily | 1-2x daily |
| Route | Oral or Subcutaneous | Intranasal spray |
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
NA-Selank reported benefits
- Enhanced anxiolytic effect
- Improved stability
- Better bioavailability
- Cognitive focus
- Stress resilience
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Research and educational reference only. Not medical advice.