Dihexa vs Selank
A side-by-side research comparison of Dihexa and Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa | Selank |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) | Selank (TP-7) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. |
| Molecular weight | 507.6 Da | 751.9 Da |
| Half-life | 6-12 hours | 3-5 min (IV) / 15-30 min (intranasal) |
| Bioavailability | Moderate (oral/SubQ) | Moderate (intranasal) |
| Typical dose | 10-20 mg (oral) or 2-5 mg (SubQ) | 250-750 mcg per spray dose |
| Frequency | Daily | 2-3x daily |
| Route | Oral or Subcutaneous | Intranasal spray |
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Related comparisons
Research and educational reference only. Not medical advice.