Dihexa vs Semax
A side-by-side research comparison of Dihexa and Semax across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa | Semax |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) | Semax (ACTH 4-10 analog) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. |
| Molecular weight | 507.6 Da | 813.9 Da |
| Half-life | 6-12 hours | 3-5 min (systemic) / extended (intranasal) |
| Bioavailability | Moderate (oral/SubQ) | Moderate (intranasal) |
| Typical dose | 10-20 mg (oral) or 2-5 mg (SubQ) | 200-600 mcg per dose |
| Frequency | Daily | 2-3x daily |
| Route | Oral or Subcutaneous | Intranasal drops/spray |
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Related comparisons
Research and educational reference only. Not medical advice.