Cortagen vs Selank
A side-by-side research comparison of Cortagen and Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortagen | Selank |
|---|---|---|
| Full name | Cortagen (Brain Cortex Peptide) | Selank (TP-7) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Regulates gene expression in cerebral cortex neurons, modulating neurotransmitter receptor density, synaptic plasticity, and neuronal energy metabolism. | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. |
| Molecular weight | ~420 Da | 751.9 Da |
| Half-life | ~2-4 hours | 3-5 min (IV) / 15-30 min (intranasal) |
| Bioavailability | ~70% oral (as capsule); ~85% subcutaneous | Moderate (intranasal) |
| Typical dose | 10 mg | 250-750 mcg per spray dose |
| Frequency | Daily for 10-15 days | 2-3x daily |
| Route | Oral capsule or subcutaneous injection | Intranasal spray |
Cortagen reported benefits
- Cerebral cortex optimization
- Cognitive function improvement
- Memory enhancement
- Neuroprotection
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
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Research and educational reference only. Not medical advice.