Cortagen vs FGL
A side-by-side research comparison of Cortagen and FGL across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Cortagen | FGL |
|---|---|---|
| Full name | Cortagen (Brain Cortex Peptide) | FGL (NCAM-Derived Peptide) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Regulates gene expression in cerebral cortex neurons, modulating neurotransmitter receptor density, synaptic plasticity, and neuronal energy metabolism. | Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement. |
| Molecular weight | ~420 Da | ~1,800 Da |
| Half-life | ~2-4 hours | 4-8 hours |
| Bioavailability | ~70% oral (as capsule); ~85% subcutaneous | Moderate (SubQ, partial BBB crossing) |
| Typical dose | 10 mg | 1-5 mg/kg (research) |
| Frequency | Daily for 10-15 days | Daily or every other day |
| Route | Oral capsule or subcutaneous injection | Subcutaneous |
Cortagen reported benefits
- Cerebral cortex optimization
- Cognitive function improvement
- Memory enhancement
- Neuroprotection
FGL reported benefits
- Synaptic plasticity
- LTP facilitation
- Memory improvement
- Neurotrophic effects
- FGFR activation
Related comparisons
Research and educational reference only. Not medical advice.