Growth Hormone Peptides: GHRP vs GHRH Explained
Growth hormone peptides work by stimulating your pituitary to release GH naturally. There are two main categories that work synergistically.
GHRH Analogs (Release Hormones)
These amplify the natural GH pulse. They work best when your body is already primed to release GH.
- CJC-1295 (no DAC): Clean pulses, short-acting
- Sermorelin: Oldest GHRH analog, well-studied
- Tesamorelin: FDA-approved for lipodystrophy
GHRP (Release Peptides)
These initiate a GH pulse even when the body isn't primed. More powerful but can affect appetite and cortisol.
- Ipamorelin: Cleanest - minimal cortisol/prolactin
- GHRP-2: Strongest GH release, moderate hunger increase
- GHRP-6: Strong GH release, significant hunger increase
- MK-677: Oral, not technically a peptide, long-acting
Optimal Stacking
Combining one GHRH + one GHRP creates synergistic GH release (1+1=3 effect). Popular stacks: Ipamorelin + CJC-1295, or GHRP-2 + CJC-1295.
Best compounds for muscle growth | Ipamorelin guide