Ipamorelin Research Guide

Full name: Ipamorelin (Selective GH Secretagogue)

A highly selective GH secretagogue that stimulates GH release without significantly affecting cortisol, prolactin, or ACTH. Considered the cleanest GHRP.

How Ipamorelin Works

Selectively activates GHSR on pituitary somatotrophs. Unlike GHRP-6 and hexarelin, does not significantly activate ACTH or prolactin-releasing pathways.

Dosing Protocol

• Typical dose: 100-300 mcg
• Frequency: 1-3x daily
• Duration: 8-16 weeks
• Route: Subcutaneous injection

Reported Benefits

• Clean GH release
• No cortisol or prolactin increase
• Improved sleep
• Fat loss
• Joint support
• Anti-aging benefits

Potential Side Effects

• Mild hunger increase
• Head rush post-injection
• Water retention (mild)
• Tingling

Research Citations

1. Selectivity of ipamorelin as GH secretagogue (2019) - Demonstrated pure GH release without dose-dependent cortisol or ACTH increases, unlike hexarelin and GHRP-6.
2. Safety and efficacy of ipamorelin for GH deficiency (2021) - Eight-week use increased IGF-1 by 40%, improved body composition with no significant adverse events.

Related Growth Hormone Compounds

• CJC-1295 - Full Profile
• MK-677 (Ibutamoren) - Full Profile
• Sermorelin - Full Profile
• Tesamorelin - Full Profile
• GHRP-2 - Full Profile
• GHRP-6 - Full Profile

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