ResearchSafe

AMT (Alpha-methyltryptamine)

Category: Psychedelics. Status: Schedule I (research compound; once a Soviet antidepressant).

A long-acting tryptamine that was briefly used as an antidepressant in the Soviet Union. It has both psychedelic and stimulant-like effects and a notably long duration.

How it works

Releases and blocks reuptake of serotonin, dopamine and norepinephrine, and activates serotonin receptors, giving mixed psychedelic and stimulant effects.

Key facts

  • Molecular weight: 174.24 g/mol
  • Half-life: Long
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 12-24 hours
  • Route: Oral

Protocol notes

  • Taken orally; notable for a very slow onset and a very long (12-24 hour) duration.
  • People must avoid serotonergic drugs and certain foods because of interaction risk.
  • The long duration means a full day-and-night is set aside.

Reported benefits

  • Historic antidepressant use
  • Long-lasting effects
  • Mixed psychedelic-stimulant profile
  • Tryptamine research compound

Possible side effects

  • Very long duration
  • Insomnia
  • Nausea
  • Raised heart rate and blood pressure
  • Serotonergic interaction risk

Community reviews of AMT

Rated 3.5 out of 5 from 2 community reviews by ResearchSafe members.

  • dakota_longevity rated it 3/5 - Slight boost in creative flow, but not a breakthrough: For me, the biggest difference was a modest lift in creative thinking during my evening study sessions – ideas came a bit faster, but the effect faded after a day and didn’t translate into any lasting mood change or productivity jump.
  • runner676 rated it 4/5 - AMT helped break through a mid‑season motivation slump: I was hitting a weird mid‑season slump, my runs felt flat and my clients' sessions left me drained. After a low dose of AMT on a Sunday night, I woke up feeling oddly sharp, like my brain got a quick tune‑up. The next few training days I was more focused, my HRV nudged up and I actually looked forward to early lifts. The buzz faded after a week, and I did notice a slight jitter on heavy leg days, so I cut back.

Compare AMT

Research and educational reference only. Not medical advice.